The carriageway between Gorsebrook Road Island and Oxley Moor Road is to undergo reconstruction and resurfacing in both directions.
The project is being fully financed by Department for Transport funding through the Maintenance of Classified Roads grant.
Works are expected to start on Monday 13 March for around 8 weeks and will take place in 8 phases.
Works will take place overnight, between 7pm and 5am on weeknights (Monday to Friday) only, with comprehensive traffic management arrangements in place to minimise disruption to residents and businesses.
The initial works will only affect the southbound carriageway before works then switch to the northbound carriageway on 3 April.
Councillor Steve Evans, Cabinet Member for City Environment, said: "It is vital to our local economy that we maintain our key city gateways to the highest standards.
"We have done everything we can to lessen the impact of works on the surrounding area and the M54.
"We apologise for any inconvenience in advance and will ensure disruption is kept to a minimum."
The diversionary routes that will be in place at the relevant times during the works are as follows:
Southbound closure: Three Tuns Lane (bridge height: 4.9 metres/16'3"), Elston Hall Lane, Kempthorne Avenue, Showell Circus, Third Avenue, Raynor Road, Cannock Road (bridge height: 4.7 metres/15' 6", Stafford Street, Stafford Road.
For HGVs/to avoid low bridges follow diversion: Stafford Road, M54 Junction 2, M54, M54 Junction 3, Newport Road, Albrighton-By-Pass, Kingswood Road, Newport Road, Holyhead Road, Wergs Road,The Rock, Tettenhall Road, Chapel Ash, Chapel Ash Island, Ring Road St Andrews, Ring Road St Peters, Stafford Street, Stafford Road.
Northbound closure:Stafford Road, Stafford Street, Cannock Road (bridge height: 4.7 metres/15' 6"), Raynor Road, Third Avenue, Showell Circus, Kempthorne Avenue, Elston Hall Lane, Three Tuns Lane (bridge height: 4.9 metres/16' 3").
For HGVs/to avoid low bridges follow diversion: Stafford Road, Stafford Street, Ring Road St Peters, Ring Road St Andrews, Chapel Ash Island, Chapel Ash, Tettenhall Road, The Rock, Wergs Road, Holyhead Road, Newport Road, Kingwood Road, Albrighton-By-Pass, Newport Road, M54 Junction 3, M54 Junction 2, Stafford Road and vice versa.
- released: Tuesday 28 February, 2017